Ki Summary

Reaction Details

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Target

Polyunsaturated fatty acid 5-lipoxygenase

Ligand

BDBM50042947

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_3921

IC50

8900±n/a nM

Citation

Sogawa, S; Nihro, Y; Ueda, H; Izumi, A; Miki, T; Matsumoto, H; Satoh, T 3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors. J Med Chem36:3904-9 (1994) [PubMed]

More Info.:

Get all data from this article, Assay Method

Polyunsaturated fatty acid 5-lipoxygenase

Name:

Polyunsaturated fatty acid 5-lipoxygenase

Synonyms:

Alox5 | Arachidonate 5-lipoxygenase | LOX5_RAT

Type:

PROTEIN

Mol. Mass.:

78082.31

Organism:

Rattus norvegicus

Description:

ChEMBL_1432947

Residue:

673

Sequence:

MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDE
ELGEIYLVKIEKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLAR
DDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLN
YSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGC
NPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPC
THQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDFH
IHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGL
FDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEA
IQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLT
VVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWH
LGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYY
YLSPDRIPNSVAI

BDBM50042947

n/a

Name

BDBM50042947

Synonyms:

1-(4-Chloro-phenyl)-3-(4-hydroxy-3-methoxy-phenyl)-propenone | 1-(4-chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one | 4'-chloro-3-methoxy-4-hydroxychalcone | CHEMBL126657 | Chalcone 4

Type

Small organic molecule

Emp. Form.

C16H13ClO3

Mol. Mass.

288.726

SMILES

COc1cc(\C=C\C(=O)c2ccc(Cl)cc2)ccc1O

Structure