| Reaction Details |
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 | Report a problem with these data |
| Target | Type-2 angiotensin II receptor |
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| Ligand | BDBM50010359 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_29023 (CHEMBL646028) |
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| IC50 | 10±n/a nM |
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| Citation |  VanAtten, MK; Ensinger, CL; Chiu, AT; McCall, DE; Nguyen, TT; Wexler, RR; Timmermans, PB A novel series of selective, non-peptide inhibitors of angiotensin II binding to the AT2 site. J Med Chem36:3985-92 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-2 angiotensin II receptor |
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| Name: | Type-2 angiotensin II receptor |
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| Synonyms: | AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41346.62 |
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| Organism: | RAT |
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| Description: | Angiotensin II AT2 0 0::P35351 |
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| Residue: | 363 |
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| Sequence: | MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFA
VNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVF
GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFY
FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK
TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLAL
PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDT
FVS
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| BDBM50010359 |
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| n/a |
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| Name | BDBM50010359 |
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| Synonyms: | (S)-5-Diphenylacetyl-1-(4-methoxy-3-methyl-benzyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid | 5-Diphenylacetyl-1-(4-methoxy-3-methyl-benzyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid | 5-diphenylcarbamoyl-1-(4-methoxy-2-methylbenzyl)-(6S)-4,5,6,7-tetrahydro-1H-imidazo[5,4-c]pyridine-6-carboxylic acid | CHEMBL294558 | PD-121981 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H29N3O4 |
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| Mol. Mass. | 495.569 |
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| SMILES | COc1ccc(Cn2cnc3CN([C@@H](Cc23)C(O)=O)C(=O)C(c2ccccc2)c2ccccc2)cc1C |
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| Structure | 
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