Reaction Details |
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Target | Menin |
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Ligand | BDBM50496333 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1298276 (CHEMBL3130541) |
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IC50 | 242±n/a nM |
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Citation | He, S; Senter, TJ; Pollock, J; Han, C; Upadhyay, SK; Purohit, T; Gogliotti, RD; Lindsley, CW; Cierpicki, T; Stauffer, SR; Grembecka, J High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interaction. J Med Chem57:1543-56 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Menin |
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Name: | Menin |
Synonyms: | MEN1 | MEN1_HUMAN | Menin/Histone-lysine N-methyltransferase MLL | SCG2 |
Type: | Protein |
Mol. Mass.: | 68022.55 |
Organism: | Homo sapiens (Human) |
Description: | O00255 |
Residue: | 610 |
Sequence: | MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPE
LTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKK
VSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSED
HAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMV
CAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLT
LYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEI
YKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGI
CKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRR
RGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAP
TASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTL
SFLKRQRKGL
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BDBM50496333 |
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n/a |
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Name | BDBM50496333 |
Synonyms: | CHEMBL3126192 |
Type | Small organic molecule |
Emp. Form. | C24H31N3O2S |
Mol. Mass. | 425.587 |
SMILES | OC(C1CCCC1)(C1CCN(CCCOc2ccc(cc2)C#N)CC1)c1nccs1 |
Structure |
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