| Reaction Details |
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 | Report a problem with these data |
| Target | Menin |
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| Ligand | BDBM50496335 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1298276 (CHEMBL3130541) |
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| IC50 | 197±n/a nM |
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| Citation |  He, S; Senter, TJ; Pollock, J; Han, C; Upadhyay, SK; Purohit, T; Gogliotti, RD; Lindsley, CW; Cierpicki, T; Stauffer, SR; Grembecka, J High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interaction. J Med Chem57:1543-56 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Menin |
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| Name: | Menin |
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| Synonyms: | MEN1 | MEN1_HUMAN | Menin/Histone-lysine N-methyltransferase MLL | SCG2 |
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| Type: | Protein |
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| Mol. Mass.: | 68022.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00255 |
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| Residue: | 610 |
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| Sequence: | MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPE
LTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKK
VSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSED
HAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMV
CAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLT
LYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEI
YKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGI
CKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRR
RGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAP
TASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTL
SFLKRQRKGL
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| BDBM50496335 |
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| n/a |
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| Name | BDBM50496335 |
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| Synonyms: | CHEMBL3126188 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H33FN2O2 |
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| Mol. Mass. | 436.5615 |
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| SMILES | OC(C1CCCC1)(C1CCN(CCCOc2ccc(cc2)C#N)CC1)c1cccc(F)c1 |
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| Structure | 
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