| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily A member 5 |
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| Ligand | BDBM50496397 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1297437 (CHEMBL3129655) |
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| IC50 | 8800±n/a nM |
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| Citation |  Olsson, RI; Jacobson, I; Iliefski, T; Boström, J; Davidsson, Ö; Fjellström, O; Björe, A; Olsson, C; Sundell, J; Gran, U; Gyll, J; Malmberg, J; Hidestål, O; Emtenäs, H; Svensson, T; Yuan, ZQ; Strandlund, G; Åstrand, A; Lindhardt, E; Linhardt, G; Forsström, E; Högberg, Å; Persson, F; Andersson, B; Rönnborg, A; Löfberg, B Lactam sulfonamides as potent inhibitors of the Kv1.5 potassium ion channel. Bioorg Med Chem Lett24:1269-73 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily A member 5 |
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| Name: | Potassium voltage-gated channel subfamily A member 5 |
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| Synonyms: | HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5 |
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| Type: | Enzyme |
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| Mol. Mass.: | 67222.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22460 |
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| Residue: | 613 |
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| Sequence: | MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDA
DSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQ
RVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQ
SGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIF
EYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANG
SGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNII
DVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGL
QILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTT
VGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQG
TQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSL
YALCLDTSRETDL
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| BDBM50496397 |
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| n/a |
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| Name | BDBM50496397 |
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| Synonyms: | CHEMBL3127409 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19FN2O3S |
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| Mol. Mass. | 362.418 |
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| SMILES | Fc1ccc(CN(C[C@@H]2CCC(=O)N2)S(=O)(=O)c2ccccc2)cc1 |r| |
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| Structure | 
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