Reaction Details |
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Target | Polyunsaturated fatty acid 5-lipoxygenase |
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Ligand | BDBM50044065 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_3972 (CHEMBL618070) |
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IC50 | 380±n/a nM |
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Citation | Unangst, PC; Connor, DT; Cetenko, WA; Sorenson, RJ; Kostlan, CR; Sircar, JC; Wright, CD; Schrier, DJ; Dyer, RD Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)- 4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity. J Med Chem37:322-8 (1994) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Polyunsaturated fatty acid 5-lipoxygenase |
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Name: | Polyunsaturated fatty acid 5-lipoxygenase |
Synonyms: | Alox5 | Arachidonate 5-lipoxygenase | LOX5_RAT |
Type: | PROTEIN |
Mol. Mass.: | 78082.31 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1432947 |
Residue: | 673 |
Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDE
ELGEIYLVKIEKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLAR
DDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLN
YSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGC
NPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPC
THQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDFH
IHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGL
FDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEA
IQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLT
VVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWH
LGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYY
YLSPDRIPNSVAI
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BDBM50044065 |
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n/a |
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Name | BDBM50044065 |
Synonyms: | 5-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-2-thioxo-thiazolidin-4-one | 5-[1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-meth-(Z)-ylidene]-2-mercapto-thiazol-4-one | CHEMBL295739 |
Type | Small organic molecule |
Emp. Form. | C18H23NO2S2 |
Mol. Mass. | 349.511 |
SMILES | CC(C)(C)c1cc(\C=C2/SC(=S)NC2=O)cc(c1O)C(C)(C)C |
Structure |
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