| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Methionine aminopeptidase 1 |
|---|
| Ligand | BDBM50497528 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1438429 (CHEMBL3384241) |
|---|
| IC50 | 3500±n/a nM |
|---|
| Citation |  Altmeyer, M; Amtmann, E; Heyl, C; Marschner, A; Scheidig, AJ; Klein, CD Beta-aminoketones as prodrugs for selective irreversible inhibitors of type-1 methionine aminopeptidases. Bioorg Med Chem Lett24:5310-4 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Methionine aminopeptidase 1 |
|---|
| Name: | Methionine aminopeptidase 1 |
|---|
| Synonyms: | Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 43220.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells. |
|---|
| Residue: | 386 |
|---|
| Sequence: | MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
|
|
|
|---|
| BDBM50497528 |
|---|
| n/a |
|---|
| Name | BDBM50497528 |
|---|
| Synonyms: | CHEMBL3337742 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H15BrClNO |
|---|
| Mol. Mass. | 304.611 |
|---|
| SMILES | Cl.CN(C)CC1Cc2cc(Br)ccc2C1=O |
|---|
| Structure | 
|
|---|
Search and Browse
