| Reaction Details |
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 | Report a problem with these data |
| Target | Methionine aminopeptidase 1 |
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| Ligand | BDBM50497520 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1438429 (CHEMBL3384241) |
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| IC50 | 12200±n/a nM |
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| Citation |  Altmeyer, M; Amtmann, E; Heyl, C; Marschner, A; Scheidig, AJ; Klein, CD Beta-aminoketones as prodrugs for selective irreversible inhibitors of type-1 methionine aminopeptidases. Bioorg Med Chem Lett24:5310-4 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Methionine aminopeptidase 1 |
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| Name: | Methionine aminopeptidase 1 |
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| Synonyms: | Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 43220.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells. |
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| Residue: | 386 |
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| Sequence: | MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
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| BDBM50497520 |
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| n/a |
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| Name | BDBM50497520 |
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| Synonyms: | CHEMBL3337747 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H10O |
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| Mol. Mass. | 158.1965 |
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| SMILES | Cc1ccc2CC(=C)C(=O)c2c1 |
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| Structure | 
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