| Reaction Details |
|---|
 | Report a problem with these data |
| Target | M17 leucyl aminopeptidase |
|---|
| Ligand | BDBM50497547 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1438460 (CHEMBL3384272) |
|---|
| Ki | 0.038000±n/a nM |
|---|
| Citation |  Mistry, SN; Drinkwater, N; Ruggeri, C; Sivaraman, KK; Loganathan, S; Fletcher, S; Drag, M; Paiardini, A; Avery, VM; Scammells, PJ; McGowan, S Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors. J Med Chem57:9168-83 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| M17 leucyl aminopeptidase |
|---|
| Name: | M17 leucyl aminopeptidase |
|---|
| Synonyms: | leucine aminopeptidase |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 67834.32 |
|---|
| Organism: | Plasmodium falciparum 3D7 |
|---|
| Description: | gi_124809582 |
|---|
| Residue: | 605 |
|---|
| Sequence: | MYFSSLCKFLPISEKEKIYLNIVKKRFCKSNIYYNNNNNNIINYNKRGLKFYPFCNNLKK
NINFVNINNKKGINFHSINKERKMASEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGG
CNVEEGLTIFLVNNPGKENGPVKISSKVNDKNVSEFLKDENMEKFNVKLGTSKHFYMFND
NKNSVAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLFRFFLE
TLFYEYMTDERFKSTDKNVNMEYIKHLGVYINNADTYKEEVEKARVYYFGTYYASQLIAA
PSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAYLSVGKGSMYPNKFIHLTYK
SKGDVKKKIALVGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPEN
VEIHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDY
IVDIATLTGAMLYSLGTSYAGVFGNNEELINKILNSSKTSNEPVWWLPIINEYRATLNSK
YADINNISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGFGVRLLTEFV
LNDAL
|
|
|
|---|
| BDBM50497547 |
|---|
| n/a |
|---|
| Name | BDBM50497547 |
|---|
| Synonyms: | CHEMBL3359694 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H21N5O3 |
|---|
| Mol. Mass. | 331.3696 |
|---|
| SMILES | CC(C)(C)NC(=O)NC(C(=O)NO)c1ccc(cc1)-n1cccn1 |
|---|
| Structure | 
|
|---|
Search and Browse
