| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
|---|
| Ligand | BDBM50039544 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_153324 |
|---|
| IC50 | 25±n/a nM |
|---|
| Citation |  Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(arylmethyl) derivatives of 9-deazaguanine. J Med Chem36:55-69 (1993) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Purine nucleoside phosphorylase |
|---|
| Name: | Purine nucleoside phosphorylase |
|---|
| Synonyms: | Inosine phosphorylase | NP | PNP | PNPH_BOVIN | Purine Nucleoside Phosphorylase (PNP) | Purine nucleoside phosphorylase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 32035.18 |
|---|
| Organism: | Bos taurus (bovine) |
|---|
| Description: | n/a |
|---|
| Residue: | 289 |
|---|
| Sequence: | MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPEST
VPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGL
NPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQ
MGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG
|
|
|
|---|
| BDBM50039544 |
|---|
| n/a |
|---|
| Name | BDBM50039544 |
|---|
| Synonyms: | 2-Amino-7-thiophen-3-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one | CHEMBL79784 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H10N4OS |
|---|
| Mol. Mass. | 246.288 |
|---|
| SMILES | Nc1nc2c(Cc3ccsc3)c[nH]c2c(=O)[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
