| Reaction Details |
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 | Report a problem with these data |
| Target | D(4) dopamine receptor |
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| Ligand | BDBM50048299 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_61151 (CHEMBL879873) |
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| Ki | 90.9±n/a nM |
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| Citation |  Wright, JL; Downing, DM; Feng, MR; Hayes, RN; Heffner, TG; MacKenzie, RG; Meltzer, LT; Pugsley, TA; Wise, LD Identification, characterization and pharmacological profile of three metabolites of (R)-(+)-1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenylcyclohexen-1- yl)methyl]pyridine (CI-1007), a dopamine autoreceptor agonist and potential antipsychotic agent. J Med Chem38:5007-14 (1996) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| D(4) dopamine receptor |
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| Name: | D(4) dopamine receptor |
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| Synonyms: | D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 48373.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21917 |
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| Residue: | 419 |
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| Sequence: | MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVA
TERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCT
ASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGR
DPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSG
PGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPG
LPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWT
PFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
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| BDBM50048299 |
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| n/a |
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| Name | BDBM50048299 |
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| Synonyms: | 4-Phenyl-1-((R)-3-phenyl-cyclohex-3-enylmethyl)-1,2,3,6-tetrahydro-pyridine | CHEMBL335545 | CI-1007 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H27N |
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| Mol. Mass. | 329.4779 |
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| SMILES | C([C@@H]1CCC=C(C1)c1ccccc1)N1CCC(=CC1)c1ccccc1 |c:4,18| |
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| Structure | 
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