Reaction Details |
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Target | Integrase |
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Ligand | BDBM50499570 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1542108 (CHEMBL3744582) |
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IC50 | 20000±n/a nM |
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Citation | Tandon, V; Urvashi, na; Yadav, P; Sur, S; Abbat, S; Tiwari, V; Hewer, R; Papathanasopoulos, MA; Raja, R; Banerjea, AC; Verma, AK; Kukreti, S; Bharatam, PV Design, Synthesis, and Biological Evaluation of 1,2-Dihydroisoquinolines as HIV-1 Integrase Inhibitors. ACS Med Chem Lett6:1065-70 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Integrase |
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Name: | Integrase |
Synonyms: | pol |
Type: | PROTEIN |
Mol. Mass.: | 32203.43 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_106649 |
Residue: | 288 |
Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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BDBM50499570 |
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n/a |
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Name | BDBM50499570 |
Synonyms: | CHEMBL3740056 |
Type | Small organic molecule |
Emp. Form. | C26H21FN2O2 |
Mol. Mass. | 412.4555 |
SMILES | COc1ccc(cc1)C1=Cc2ccc(F)cc2C(CC(C)=O)N1c1ccc(cc1)C#N |t:9| |
Structure |
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