Reaction Details |
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Target | Legumain |
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Ligand | BDBM50499750 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1540559 (CHEMBL3744013) |
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IC50 | 49±n/a nM |
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Citation | Ness, KA; Eddie, SL; Higgins, CA; Templeman, A; D'Costa, Z; Gaddale, KK; Bouzzaoui, S; Jordan, L; Janssen, D; Harrison, T; Burkamp, F; Young, A; Burden, R; Scott, CJ; Mullan, PB; Williams, R Development of a potent and selective cell penetrant Legumain inhibitor. Bioorg Med Chem Lett25:5642-5 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Legumain |
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Name: | Legumain |
Synonyms: | 3.4.22.34 | Asparaginyl endopeptidase | LGMN | LGMN_HUMAN | PRSC1 | Protease, cysteine 1 |
Type: | n/a |
Mol. Mass.: | 49411.12 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 433 |
Sequence: | MVWKVAVFLSVALGIGAVPIDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNG
IPDEQIVVMMYDDIAYSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGD
AEAVKGIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYKHKMYR
KMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKRSTYLGDWYSVNWMED
SDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTISTMKVMQFQGMKRKASSPVPLPPVT
HLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDARHLIEKSVRKIVSLLAASE
AEVEQLLSERAPLTGHSCYPEALLHFRTHCFNWHSPTYEYALRHLYVLVNLCEKPYPLHR
IKLSMDHVCLGHY
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BDBM50499750 |
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n/a |
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Name | BDBM50499750 |
Synonyms: | CHEMBL3741002 |
Type | Small organic molecule |
Emp. Form. | C22H22N4O6S |
Mol. Mass. | 470.498 |
SMILES | NC(=O)C[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(cc1)-c1ccc2OCOc2c1)C#N |r| |
Structure |
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