| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid 5-lipoxygenase |
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| Ligand | BDBM50048992 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_3905 (CHEMBL619910) |
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| IC50 | 240±n/a nM |
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| Citation |  Hamer, RR; Tegeler, JJ; Kurtz, ES; Allen, RC; Bailey, SC; Elliott, ME; Hellyer, L; Helsley, GC; Przekop, P; Freed, BS; White, J; Martin, LL Dibenzoxepinone hydroxylamines and hydroxamic acids: dual inhibitors of cyclooxygenase and 5-lipoxygenase with potent topical antiinflammatory activity. J Med Chem39:246-52 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid 5-lipoxygenase |
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| Name: | Polyunsaturated fatty acid 5-lipoxygenase |
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| Synonyms: | Alox5 | Arachidonate 5-lipoxygenase | LOX5_RAT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 78082.31 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1432947 |
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| Residue: | 673 |
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| Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDE
ELGEIYLVKIEKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLAR
DDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLN
YSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGC
NPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPC
THQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDFH
IHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGL
FDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEA
IQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLT
VVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWH
LGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYY
YLSPDRIPNSVAI
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| BDBM50048992 |
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| n/a |
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| Name | BDBM50048992 |
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| Synonyms: | 2-[2-(Hydroxy-methyl-amino)-ethyl]-6H-dibenzo[b,e]oxepin-11-one | CHEMBL83990 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17NO3 |
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| Mol. Mass. | 283.3218 |
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| SMILES | CN(O)CCc1ccc2OCc3ccccc3C(=O)c2c1 |
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| Structure | 
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