| Reaction Details |
|---|
 | Report a problem with these data |
| Target | CAAX prenyl protease 2 |
|---|
| Ligand | BDBM50500091 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1541784 (CHEMBL3742598) |
|---|
| IC50 | 7100±n/a nM |
|---|
| Citation |  Mohammed, I; Hampton, SE; Ashall, L; Hildebrandt, ER; Kutlik, RA; Manandhar, SP; Floyd, BJ; Smith, HE; Dozier, JK; Distefano, MD; Schmidt, WK; Dore, TM 8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells. Bioorg Med Chem24:160-78 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| CAAX prenyl protease 2 |
|---|
| Name: | CAAX prenyl protease 2 |
|---|
| Synonyms: | CAAX prenyl protease 2 | FACE-2 | FACE2 | FACE2_HUMAN | Farnesylated proteins-converting enzyme 2 | Prenyl protein specific protease | Prenyl protein-specific endoprotease 2 | RCE1 | RCE1 homolog | RCE1A | RCE1B | hRCE1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 35839.94 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_194935 |
|---|
| Residue: | 329 |
|---|
| Sequence: | MAALGGDGLRLLSVSRPERPPESAALGGLGPGLCCWVSVFSCLSLACSYVGSLYVWKSEL
PRDHPAVIKRRFTSVLVVSSLSPLCVLLWRELTGIQPGTSLLTLMGFRLEGIFPAALLPL
LLTMILFLGPLMQLSMDCPCDLADGLKVVLAPRSWARCLTDMRWLRNQVIAPLTEELVFR
ACMLPMLAPCMGLGPAVFTCPLFFGVAHFHHIIEQLRFRQSSVGNIFLSAAFQFSYTAVF
GAYTAFLFIRTGHLIGPVLCHSFCNYMGFPAVCAALEHPQRRPLLAGYALGVGLFLLLLQ
PLTDPKLYGSLPLCVLLERAGDSEAPLCS
|
|
|
|---|
| BDBM50500091 |
|---|
| n/a |
|---|
| Name | BDBM50500091 |
|---|
| Synonyms: | CHEMBL3740563 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H20N2O3 |
|---|
| Mol. Mass. | 384.4272 |
|---|
| SMILES | Cc1ccc(cc1)C(Nc1ccc(cc1)C(O)=O)c1ccc2cccnc2c1O |
|---|
| Structure | 
|
|---|
Search and Browse
