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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Neuronal acetylcholine receptor subunit alpha-7 | ||
| Ligand | BDBM50500419 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1546366 (CHEMBL3748597) | ||
| Ki | >1000±n/a nM | ||
| Citation |  Ouach, A; Pin, F; Bertrand, E; Vercouillie, J; Gulhan, Z; Mothes, C; Deloye, JB; Guilloteau, D; Suzenet, F; Chalon, S; Routier, S Design of ?7 nicotinic acetylcholine receptor ligands using the (het)Aryl-1,2,3-triazole core: Synthesis, in vitro evaluation and SAR studies. Eur J Med Chem107:153-64 (2016) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Neuronal acetylcholine receptor subunit alpha-7 | |||
| Name: | Neuronal acetylcholine receptor subunit alpha-7 | ||
| Synonyms: | ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 56502.44 | ||
| Organism: | Rattus norvegicus (Rat) | ||
| Description: | Q05941 | ||
| Residue: | 502 | ||
| Sequence: |
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| BDBM50500419 | |||
| n/a | |||
| Name | BDBM50500419 | ||
| Synonyms: | CHEMBL3746181 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H19FN4O | ||
| Mol. Mass. | 302.3467 | ||
| SMILES | COc1ccc(cc1)-n1cc(nn1)C1(F)CN2CCC1CC2 |THB:14:13:18.17:20.21,10:13:18.17:20.21,(-10.3,1.6,;-9.66,.55,;-8.12,.58,;-7.32,-.73,;-5.78,-.69,;-5.04,.66,;-5.84,1.97,;-7.38,1.94,;-3.51,.81,;-2.48,-.34,;-1.09,.29,;-1.23,1.81,;-2.73,2.14,;.25,-.49,;1.3,.14,;1.76,-2.89,;-.88,-3.53,;.22,-2.89,;.22,-1.61,;-.88,-.99,;-1.96,-1.61,;-1.96,-2.89,)| | ||
| Structure | 
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