Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50050390 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_55115 (CHEMBL665442) |
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IC50 | 430.0±n/a nM |
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Citation | Piper, JR; Johnson, CA; Krauth, CA; Carter, RL; Hosmer, CA; Queener, SF; Borotz, SE; Pfefferkorn, ER Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations. J Med Chem39:1271-80 (1996) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21638.84 |
Organism: | Rattus norvegicus (rat) |
Description: | n/a |
Residue: | 187 |
Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKF
EVYEKKD
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BDBM50050390 |
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n/a |
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Name | BDBM50050390 |
Synonyms: | 5-Methyl-6-phenylsulfanylmethyl-pyrido[2,3-d]pyrimidine-2,4-diamine | CHEMBL291239 |
Type | Small organic molecule |
Emp. Form. | C15H15N5S |
Mol. Mass. | 297.378 |
SMILES | Cc1c(CSc2ccccc2)cnc2nc(N)nc(N)c12 |
Structure |
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