| Reaction Details |
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 | Report a problem with these data |
| Target | Plasmepsin V |
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| Ligand | BDBM50500851 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1563469 (CHEMBL3783062) |
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| IC50 | 0.800000±n/a nM |
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| Citation |  Gazdik, M; Jarman, KE; O'Neill, MT; Hodder, AN; Lowes, KN; Jousset Sabroux, H; Cowman, AF; Boddey, JA; Sleebs, BE Exploration of the P3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V. Bioorg Med Chem24:1993-2010 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasmepsin V |
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| Name: | Plasmepsin V |
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| Synonyms: | Plasmepsin V |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68485.65 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | ChEMBL_109726 |
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| Residue: | 590 |
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| Sequence: | MNNYFLRKENFFILFCFVFVSIFFVSNVTIIKCNNVENKIDNVGKKIENVGKKIGDMENK
NDNVENKNDNVGNKNDNVKNASSDLYKYKLYGDIDEYAYYFLDIDIGKPSQRISLILDTG
SSSLSFPCNGCKDCGIHMEKPYNLNYSKTSSILYCNKSNCPYGLKCVGNKCEYLQSYCEG
SQIYGFYFSDIVTLPSYNNKNKISFEKLMGCHMHEESLFLHQQATGVLGFSLTKPNGVPT
FVDLLFKHTPSLKPIYSICVSEHGGELIIGGYEPDYFLSNQKEKQKMDKSDNNSSNKGNV
SIKLKNNDKNDDEENNSKDVIVSNNVEDIVWQAITRKYYYYIKIYGLDLYGTNIMDKKEL
DMLVDSGSTFTHIPENIYNQINYYLDILCIHDMTNIYEINKRLKLTNESLNKPLVYFEDF
KTALKNIIQNENLCIKIVDGVQCWKSLENLPNLYITLSNNYKMIWKPSSYLYKKESFWCK
GLEKQVNNKPILGLTFFKNKQVIFDLQQNQIAFIESKCPSNLTSSRPRTFNEYREKENIF
LKVSYINLYCLWLLLALTILLSLILYVRKMFYMDYFPLSDQNKSPIQEST
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| BDBM50500851 |
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| n/a |
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| Name | BDBM50500851 |
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| Synonyms: | CHEMBL3780033 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H52F3N7O9 |
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| Mol. Mass. | 783.8348 |
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| SMILES | OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCONC(N)=N)NC(=O)OCc1ccccc1)C(C)C)[C@@H](O)CC(=O)NCCc1ccccc1 |r| |
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| Structure | 
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