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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Prolyl endopeptidase | ||
| Ligand | BDBM50051517 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_158375 (CHEMBL769576) | ||
| IC50 | 24±n/a nM | ||
| Citation |  Portevin, B; Benoist, A; Rémond, G; Hervé, Y; Vincent, M; Lepagnol, J; De Nanteuil, G New prolyl endopeptidase inhibitors: in vitro and in vivo activities of azabicyclo[2.2.2]octane, azabicyclo[2.2.1]heptane, and perhydroindole derivatives. J Med Chem39:2379-91 (1996) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Prolyl endopeptidase | |||
| Name: | Prolyl endopeptidase | ||
| Synonyms: | PE | PEP | POP | PPCE_HUMAN | PREP | Post-proline cleaving enzyme | Prolyl oligopeptidase | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 80688.50 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P48147 | ||
| Residue: | 710 | ||
| Sequence: |
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| BDBM50051517 | |||
| n/a | |||
| Name | BDBM50051517 | ||
| Synonyms: | (R)-3-(Thiazolidine-3-carbonyl)-2-aza-bicyclo[2.2.2]octane-2-carboxylic acid tert-butyl ester | CHEMBL311879 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H26N2O3S | ||
| Mol. Mass. | 326.454 | ||
| SMILES | CC(C)(C)OC(=O)N1C2CCC(CC2)[C@@H]1C(=O)N1CCSC1 |wD:14.16,(11.41,-17.05,;11.41,-15.5,;10.07,-14.73,;12.9,-15.9,;12.75,-14.73,;12.75,-13.19,;14.08,-12.42,;11.41,-12.42,;10.08,-13.19,;8.75,-12.42,;8.75,-10.88,;10.08,-10.1,;9.3,-11.44,;10.78,-11.03,;11.41,-10.88,;12.75,-10.1,;14.08,-10.89,;12.76,-8.56,;14.01,-7.67,;13.53,-6.18,;12,-6.19,;11.52,-7.65,)| | ||
| Structure | 
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