| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 11B1, mitochondrial |
|---|
| Ligand | BDBM50502510 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1807731 (CHEMBL4307090) |
|---|
| IC50 | 4171±n/a nM |
|---|
| Citation |  Sparks, SM; Danger, DP; Hoekstra, WJ; Leesnitzer, T; Schotzinger, RJ; Yates, CM; Becherer, JD Development of Highly Selective Pyrimidine-Based Aldosterone Synthase (CYP11B2) Inhibitors. ACS Med Chem Lett10:1056-1060 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 11B1, mitochondrial |
|---|
| Name: | Cytochrome P450 11B1, mitochondrial |
|---|
| Synonyms: | C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 57591.44 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P15538 |
|---|
| Residue: | 503 |
|---|
| Sequence: | MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN
|
|
|
|---|
| BDBM50502510 |
|---|
| n/a |
|---|
| Name | BDBM50502510 |
|---|
| Synonyms: | CHEMBL4474610 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H10F3N5 |
|---|
| Mol. Mass. | 329.2793 |
|---|
| SMILES | FC(F)(F)c1ncncc1-c1nc2ccc(cc2n1C1CC1)C#N |
|---|
| Structure | 
|
|---|
Search and Browse
