| Reaction Details |
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 | Report a problem with these data |
| Target | Tumor necrosis factor |
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| Ligand | BDBM50052616 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_212401 (CHEMBL815988) |
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| IC50 | 70000±n/a nM |
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| Citation |  Muller, GW; Corral, LG; Shire, MG; Wang, H; Moreira, A; Kaplan, G; Stirling, DI Structural modifications of thalidomide produce analogs with enhanced tumor necrosis factor inhibitory activity. J Med Chem39:3238-40 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tumor necrosis factor |
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| Name: | Tumor necrosis factor |
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| Synonyms: | Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha |
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| Type: | Enzyme |
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| Mol. Mass.: | 25645.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P01375 |
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| Residue: | 233 |
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| Sequence: | MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
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| BDBM50052616 |
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| n/a |
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| Name | BDBM50052616 |
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| Synonyms: | 3-(3,4-Dichloro-phenyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionamide | CHEMBL320347 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12Cl2N2O3 |
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| Mol. Mass. | 363.195 |
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| SMILES | NC(=O)CC(N1C(=O)c2ccccc2C1=O)c1ccc(Cl)c(Cl)c1 |
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| Structure | 
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