| Reaction Details |
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 | Report a problem with these data |
| Target | Retinoic acid receptor RXR-gamma |
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| Ligand | BDBM50502769 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1808822 (CHEMBL4308181) |
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| EC50 | 3300±n/a nM |
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| Citation |  Pollinger, J; Schierle, S; Gellrich, L; Ohrndorf, J; Kaiser, A; Heitel, P; Chaikuad, A; Knapp, S; Merk, D A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences. ACS Med Chem Lett10:1346-1352 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinoic acid receptor RXR-gamma |
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| Name: | Retinoic acid receptor RXR-gamma |
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| Synonyms: | NR2B3 | Nuclear receptor subfamily 2 group B member 3 | RXRG | RXRG_HUMAN | Retinoic acid receptor RXR-gamma | Retinoid X receptor gamma | Retinoid X receptor gamma/retinoic acid receptor alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50878.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_197216 |
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| Residue: | 463 |
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| Sequence: | MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVG
TPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPG
IGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKD
CLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERIL
EAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVI
LLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKD
MQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLL
LRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT
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| BDBM50502769 |
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| n/a |
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| Name | BDBM50502769 |
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| Synonyms: | CHEMBL4578667 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H28O2 |
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| Mol. Mass. | 324.4565 |
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| SMILES | CC(C)(C)c1cc(cc(c1)C(C)(C)C)-c1ccc(CC(O)=O)cc1 |
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| Structure | 
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