| Reaction Details |
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 | Report a problem with these data |
| Target | Procathepsin L |
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| Ligand | BDBM50502845 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1808997 (CHEMBL4308356) |
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| Ki | 1585±n/a nM |
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| Citation |  Gomes, JC; Cianni, L; Ribeiro, J; Dos Reis Rocho, F; da Costa Martins Silva, S; Batista, PHJ; Moraes, CB; Franco, CH; Freitas-Junior, LHG; Kenny, PW; Leitão, A; Burtoloso, ACB; de Vita, D; Montanari, CA Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement. Bioorg Med Chem27:0 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Procathepsin L |
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| Name: | Procathepsin L |
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| Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
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| Type: | Enzyme |
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| Mol. Mass.: | 37557.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purchased from Calbiochem (San Diego, CA). |
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| Residue: | 333 |
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| Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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| BDBM50502845 |
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| n/a |
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| Name | BDBM50502845 |
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| Synonyms: | CHEMBL4456233 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H26F3N3O2 |
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| Mol. Mass. | 481.5094 |
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| SMILES | COc1ccc(C[C@H](N[C@H](c2ccccc2)C(F)(F)F)C(=O)N[C@@H](Cc2ccccc2)C#N)cc1 |r| |
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| Structure | 
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