| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate receptor ionotropic, NMDA 2D |
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| Ligand | BDBM50083351 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1809541 (CHEMBL4309001) |
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| IC50 | 75900±n/a nM |
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| Citation |  Burnell, ES; Irvine, M; Fang, G; Sapkota, K; Jane, DE; Monaghan, DT Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action. J Med Chem62:3-23 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate receptor ionotropic, NMDA 2D |
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| Name: | Glutamate receptor ionotropic, NMDA 2D |
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| Synonyms: | GRIN2D | GluN2D | Glutamate [NMDA] receptor subunit epsilon 4 | Ionotropic glutamate receptor NMDA 1/2D | NMDAR2D | NMDE4_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 143780.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_983632 |
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| Residue: | 1336 |
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| Sequence: | MRGAGGPRGPRGPAKMLLLLALACASPFPEEAPGPGGAGGPGGGLGGARPLNVALVFSGP
AYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDD
SRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLE
EYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLSAQLRSVS
AQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPL
PAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRAQNRTHRGESL
HRYFMNITWDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYG
RFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPE
KRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSL
TINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVT
VFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVL
VWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEK
NIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGS
GKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKL
DIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAE
AAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLADG
FHRYYGPIEPQGLGLGLGEARAAPRGAAGRPLSPPAAQPPQKPPPSYFAIVRDKEPAEPP
AGAFPGFPSPPAPPAAAATAVGPPLCRLAFEDESPPAPARWPRSDPESQPLLGPGAGGAG
GTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYP
YAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHCRHCASLELLPPPRHLSCSHD
GLDGGWWAPPPPPWAAGPLPRRRARCGCPRSHPHRPRASHRTPAAAAPHHHRHRRAAGGW
DLPPPAPTSRSLEDLSSCPRAAPARRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGDL
GTRRGSAHFSSLESEV
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| BDBM50083351 |
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| n/a |
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| Name | BDBM50083351 |
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| Synonyms: | (+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol] | -(2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl)phenol | 4-(2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl)phenol | 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-propyl]-phenol | CHEMBL305187 | ChEMBL_104385 | IFENPRODIL |
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| Type | Small organic molecule |
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| Emp. Form. | C21H27NO2 |
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| Mol. Mass. | 325.4446 |
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| SMILES | CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 |
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| Structure | 
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