| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 |
|---|
| Ligand | BDBM65549 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1810510 (CHEMBL4309970) |
|---|
| IC50 | 3.0±n/a nM |
|---|
| Citation |  Jorda, R; Hendrychová, D; Voller, J; ?ezní?ková, E; Gucký, T; Kry?tof, V How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases? J Med Chem61:9105-9120 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 |
|---|
| Name: | Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 |
|---|
| Synonyms: | CDK2/CycE | CDK2/Cyclin E | CDK2/E | CDK2/E1 | Cyclin-Dependent Kinase 2 (CDK2) | Cyclin-dependent kinase 2/G1/S-specific cyclin E1 | Cyclin-dependent kinase 2/cyclin E1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Cyclin-dependent kinase 2 |
|---|
| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 33938.17 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P24941 |
|---|
| Residue: | 298 |
|---|
| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
|
|
|
|---|
| Component 2 |
| Name: | G1/S-specific cyclin-E1 |
|---|
| Synonyms: | CCNE | CCNE1 | CCNE1_HUMAN |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 47073.17 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 410 |
|---|
| Sequence: | MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQ
PWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIM
LNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQ
ENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWR
LSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILA
ASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNI
QTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA
|
|
|
|---|
| BDBM65549 |
|---|
| n/a |
|---|
| Name | BDBM65549 |
|---|
| Synonyms: | 3-[[4-[2-(3-chloroanilino)-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol | 3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]-2-pyridyl]amino]propan-1-ol | 3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol | 3-[[4-[2-[(3-chlorophenyl)amino]pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol | MLS000911536 | SMR000463552 | cid_644215 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H18ClN5O |
|---|
| Mol. Mass. | 355.821 |
|---|
| SMILES | OCCCNc1cc(ccn1)-c1ccnc(Nc2cccc(Cl)c2)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
