| Reaction Details |
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 | Report a problem with these data |
| Target | CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 |
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| Ligand | BDBM6878 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1810514 (CHEMBL4309974) |
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| IC50 | 66±n/a nM |
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| Citation |  Jorda, R; Hendrychová, D; Voller, J; ?ezní?ková, E; Gucký, T; Kry?tof, V How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases? J Med Chem61:9105-9120 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 |
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| Name: | CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 |
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| Synonyms: | CDK-activating kinase assembly factor MAT1/Cyclin H/Cyclin-dependent kinase 7 | CDK7/Cyclin H/MNAT1 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 3 components. |
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| Component 1 |
| Name: | Cyclin-dependent kinase 7 |
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| Synonyms: | 39 kDa protein kinase | CAK | CAK1 | CDK-activating kinase | CDK-activating kinase 1 (CAK) | CDK7 | CDK7_HUMAN | CDKN7 | Cell division protein kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7 (CDK7/cyclin H) | MO15 | P39 Mo15 | STK1 | TFIIH basal transcription factor complex kinase subunit |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 39047.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 346 |
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| Sequence: | MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL
REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM
TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA
PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM
CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG
PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
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| Component 2 |
| Name: | Cyclin-H |
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| Synonyms: | CCNH | CCNH_HUMAN | Cyclin H | MO15-associated protein | p34 | p37 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 37646.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 323 |
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| Sequence: | MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYY
EKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNV
SSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPI
LENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKE
NRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDD
DYVSKKSKHEEEEWTDDDLVESL
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| Component 3 |
| Name: | CDK-activating kinase assembly factor MAT1 |
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| Synonyms: | CAP35 | CDK7/cyclin-H assembly factor | Cyclin-G1-interacting protein | MAT1 | MAT1_HUMAN | MNAT1 | Menage a trois | RING finger protein 66 | RING finger protein MAT1 | RNF66 | p35 | p36 |
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| Type: | Enzyme |
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| Mol. Mass.: | 35820.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51948 |
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| Residue: | 309 |
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| Sequence: | MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRV
QLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKK
KMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNK
QAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHK
LEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDA
FSGLFWQPS
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| BDBM6878 |
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| n/a |
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| Name | BDBM6878 |
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| Synonyms: | 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3n | 5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphenyl)amino]-1H-1,2,4-triazole-1-carbothioamide |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13F2N7O2S2 |
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| Mol. Mass. | 425.436 |
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| SMILES | Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=S)Nc1c(F)cccc1F |
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| Structure | 
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