| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain-containing protein 3 |
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| Ligand | BDBM50503387 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1810632 (CHEMBL4310092) |
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| IC50 | 110000±n/a nM |
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| Citation |  Divakaran, A; Talluri, SK; Ayoub, AM; Mishra, NK; Cui, H; Widen, JC; Berndt, N; Zhu, JY; Carlson, AS; Topczewski, JJ; Schonbrunn, EK; Harki, DA; Pomerantz, WCK Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor. J Med Chem61:9316-9334 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain-containing protein 3 |
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| Name: | Bromodomain-containing protein 3 |
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| Synonyms: | BRD3 | BRD3_HUMAN | Bromodomain and extra-terminal motif (BET) | Bromodomain-containing protein 3 | Bromodomain-containing protein 3 (BRD3) | KIAA0043 | RING3-like protein | RING3L |
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| Type: | Protein |
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| Mol. Mass.: | 79571.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q15059 |
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| Residue: | 726 |
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| Sequence: | MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFY
QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTD
DIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPA
TPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKK
GVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQ
HAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLST
VKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPV
EAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAAL
SQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKA
NSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQ
SREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEEL
AQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSS
DSSDSE
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| BDBM50503387 |
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| n/a |
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| Name | BDBM50503387 |
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| Synonyms: | CHEMBL4475135 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H26FN7 |
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| Mol. Mass. | 443.5192 |
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| SMILES | Cc1cc(C)cc(Nc2nccc(n2)-c2c(nnn2C2CCNCC2)-c2ccc(F)cc2)c1 |
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| Structure | 
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