| Reaction Details |
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 | Report a problem with these data |
| Target | D(1A) dopamine receptor |
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| Ligand | BDBM50054143 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_60193 (CHEMBL879565) |
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| IC50 | 22400±n/a nM |
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| Citation |  Comoy, C; Marot, C; Podona, T; Baudin, ML; Morin-Allory, L; Guillaumet, G; Pfeiffer, B; Caignard, DH; Renard, P; Rettori, MC; Adam, G; Guardiola-Lemaitre, B 3-amino-3,4-dihydro-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 2. Synthesis and quantitative structure-activity relationship studies of spiro[pyrrolidine- and piperidine-2,3'(2'H)-benzopyrans] J Med Chem39:4285-98 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D(1A) dopamine receptor |
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| Name: | D(1A) dopamine receptor |
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| Synonyms: | D(1A) dopamine receptor | D1AR | DOPAMINE D1 | DRD1 | DRD1_BOVIN | Dopamine receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 49330.65 |
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| Organism: | BOVINE |
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| Description: | DOPAMINE D1 DRD1 BOVINE::Q95136 |
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| Residue: | 446 |
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| Sequence: | MRTLNTSTMEGTGLVAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTGPSEGNATSLG
KTINNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKN
CQTTTGNGNPMECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGS
GETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTTNNAIET
VSINNNGAVVFSSHHEPRGSISKDCNVVYLIPHAVGSSEGLKKEEAVGIAKPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
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| BDBM50054143 |
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| n/a |
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| Name | BDBM50054143 |
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| Synonyms: | (+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-(tetrahydro-1'H-pyrrole)]-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione | (+/-) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-(tetrahydro-1'H-pyrrole)]-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione | (-) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-(tetrahydro-1'H-pyrrole)]-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione | 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-(tetrahydro-1'H-pyrrole)]-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione | CHEMBL11265 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H36N2O4 |
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| Mol. Mass. | 440.575 |
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| SMILES | COc1cccc2OCC3(CCCN3CCCCN3C(=O)CC4(CCCC4)CC3=O)Cc12 |
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| Structure | 
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