| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 1B1 |
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| Ligand | BDBM89011 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1812125 (CHEMBL4311585) |
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| IC50 | 43±n/a nM |
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| Citation |  Kubo, M; Yamamoto, K; Itoh, T Design and synthesis of selective CYP1B1 inhibitor via dearomatization of ?-naphthoflavone. Bioorg Med Chem27:285-304 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 1B1 |
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| Name: | Cytochrome P450 1B1 |
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| Synonyms: | CP1B1_HUMAN | CYP1B1 | CYPIB1 | Cytochrome P450 1B1 (CYP1B1) |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60861.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1474523 |
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| Residue: | 543 |
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| Sequence: | MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLI
GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAF
ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL
LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL
VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSA
EKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAEL
DQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVV
FVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQL
FLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNLQAKE
TCQ
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| BDBM89011 |
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| n/a |
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| Name | BDBM89011 |
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| Synonyms: | 2-(4-hydroxyphenyl)-4-benzo[h][1]benzopyranone | 2-(4-hydroxyphenyl)benzo[h]chromen-4-one | 4'-HYDROXY-a-NAPHTHOFLAVONE | MLS001360579 | SMR001223867 | cid_676300 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H12O3 |
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| Mol. Mass. | 288.2968 |
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| SMILES | Oc1ccc(cc1)-c1cc(=O)c2ccc3ccccc3c2o1 |
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| Structure | 
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