| Reaction Details |
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 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP10 |
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| Ligand | BDBM50503868 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1812376 (CHEMBL4311836) |
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| IC50 | 2239±n/a nM |
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| Citation |  Morgan, RK; Kirby, IT; Vermehren-Schmaedick, A; Rodriguez, K; Cohen, MS Rational Design of Cell-Active Inhibitors of PARP10. ACS Med Chem Lett10:74-79 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein mono-ADP-ribosyltransferase PARP10 |
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| Name: | Protein mono-ADP-ribosyltransferase PARP10 |
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| Synonyms: | 2.4.2.- | 2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 10 | ARTD10 | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD10 or PARP10, L926Y)) | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD10 or PARP10, R931A)) | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD10 or PARP10, S927A)) | PAR10_HUMAN | PARP-10 | PARP10 | Poly [ADP-ribose] polymerase 10 |
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| Type: | n/a |
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| Mol. Mass.: | 109953.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q53GL7 |
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| Residue: | 1025 |
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| Sequence: | MVAMAEAEAGVAVEVRGLPPAVPDELLTLYFENRRRSGGGPVLSWQRLGCGGVLTFREPA
DAERVLAQADHELHGAQLSLRPAPPRAPARLLLQGLPPGTTPQRLEQHVQALLRASGLPV
QPCCALASPRPDRALVQLPKPLSEADVRVLEEQAQNLGLEGTLVSLARVPQARAVRVVGD
GASVDLLLLELYLENERRSGGGPLEDLQRLPGPLGTVASFQQWQVAERVLQQEHRLQGSE
LSLVPHYDILEPEELAENTSGGDHPSTQGPRATKHALLRTGGLVTALQGAGTVTMGSGEE
PGQSGASLRTGPMVQGRGIMTTGSGQEPGQSGTSLRTGPMGSLGQAEQVSSMPMGSLEHE
GLVSLRPVGLQEQEGPMSLGPVGSAGPVETSKGLLGQEGLVEIAMDSPEQEGLVGPMEIT
MGSLEKAGPVSPGCVKLAGQEGLVEMVLLMEPGAMRFLQLYHEDLLAGLGDVALLPLEGP
DMTGFRLCGAQASCQAAEEFLRSLLGSISCHVLCLEHPGSARFLLGPEGQHLLQGLEAQF
QCVFGTERLATATLDTGLEEVDPTEALPVLPGNAHTLWTPDSTGGDQEDVSLEEVRELLA
TLEGLDLDGEDWLPRELEEEGPQEQPEEEVTPGHEEEEPVAPSTVAPRWLEEEAALQLAL
HRSLEPQGQVAEQEEAAALRQALTLSLLEQPPLEAEEPPDGGTDGKAQLVVHSAFEQDVE
ELDRALRAALEVHVQEETVGPWRRTLPAELRARLERCHGVSVALRGDCTILRGFGAHPAR
AARHLVALLAGPWDQSLAFPLAASGPTLAGQTLKGPWNNLERLAENTGEFQEVVRAFYDT
LDAARSSIRVVRVERVSHPLLQQQYELYRERLLQRCERRPVEQVLYHGTTAPAVPDICAH
GFNRSFCGRNATVYGKGVYFARRASLSVQDRYSPPNADGHKAVFVARVLTGDYGQGRRGL
RAPPLRGPGHVLLRYDSAVDCICQPSIFVIFHDTQALPTHLITCEHVPRASPDDPSGLPG
RSPDT
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| BDBM50503868 |
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| n/a |
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| Name | BDBM50503868 |
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| Synonyms: | CHEMBL4452747 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12F3NO |
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| Mol. Mass. | 291.2678 |
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| SMILES | FC(F)(F)c1cccc(c1)-c1ccc2C(=O)NCCc2c1 |
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| Structure | 
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