| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP11 |
|---|
| Ligand | BDBM50503868 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1812377 (CHEMBL4311837) |
|---|
| IC50 | 17378±n/a nM |
|---|
| Citation |  Morgan, RK; Kirby, IT; Vermehren-Schmaedick, A; Rodriguez, K; Cohen, MS Rational Design of Cell-Active Inhibitors of PARP10. ACS Med Chem Lett10:74-79 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein mono-ADP-ribosyltransferase PARP11 |
|---|
| Name: | Protein mono-ADP-ribosyltransferase PARP11 |
|---|
| Synonyms: | 2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 11 | ARTD11 | C12orf6 | PAR11_HUMAN | PARP-11 | PARP11 | Poly [ADP-ribose] polymerase 11 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 39601.40 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_107591 |
|---|
| Residue: | 338 |
|---|
| Sequence: | MWEANPEMFHKAEELFSKTTNNEVDDMDTSDTQWGWFYLAECGKWHMFQPDTNSQCSVSS
EDIEKSFKTNPCGSISFTTSKFSYKIDFAEMKQMNLTTGKQRLIKRAPFSISAFSYICEN
EAIPMPPHWENVNTQVPYQLIPLHNQTHEYNEVANLFGKTMDRNRIKRIQRIQNLDLWEF
FCRKKAQLKKKRGVPQINEQMLFHGTSSEFVEAICIHNFDWRINGIHGAVFGKGTYFARD
AAYSSRFCKDDIKHGNTFQIHGVSLQQRHLFRTYKSMFLARVLIGDYINGDSKYMRPPSK
DGSYVNLYDSCVDDTWNPKIFVVFDANQIYPEYLIDFH
|
|
|
|---|
| BDBM50503868 |
|---|
| n/a |
|---|
| Name | BDBM50503868 |
|---|
| Synonyms: | CHEMBL4452747 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H12F3NO |
|---|
| Mol. Mass. | 291.2678 |
|---|
| SMILES | FC(F)(F)c1cccc(c1)-c1ccc2C(=O)NCCc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
