| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 1 |
|---|
| Ligand | BDBM50504644 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1815920 (CHEMBL4315494) |
|---|
| IC50 | 13160±n/a nM |
|---|
| Citation |  Shawky, AM; Abourehab, MAS; Abdalla, AN; Gouda, AM Optimization of pyrrolizine-based Schiff bases with 4-thiazolidinone motif: Design, synthesis and investigation of cytotoxicity and anti-inflammatory potency. Eur J Med Chem185:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostaglandin G/H synthase 1 |
|---|
| Name: | Prostaglandin G/H synthase 1 |
|---|
| Synonyms: | COX-1 | COX1 | Cyclooxygenase | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_HUMAN | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 68692.62 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P23219 |
|---|
| Residue: | 599 |
|---|
| Sequence: | MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR
TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS
NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF
LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ
YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY
ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF
DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA
LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL
VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS
PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
|
|
|
|---|
| BDBM50504644 |
|---|
| n/a |
|---|
| Name | BDBM50504644 |
|---|
| Synonyms: | CHEMBL4454216 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H15BrN4O2 |
|---|
| Mol. Mass. | 423.263 |
|---|
| SMILES | Brc1ccc(NC(=O)c2c(\N=C\c3ccco3)c(C#N)c3CCCn23)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
