Reaction Details |
| Report a problem with these data |
Target | Endothelin receptor type B |
---|
Ligand | BDBM50056080 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_63873 (CHEMBL671335) |
---|
IC50 | 11000±n/a nM |
---|
Citation | Tasker, AS; Sorensen, BK; Jae, HS; Winn, M; von Geldern, TW; Dixon, DB; Chiou, WJ; Dayton, BD; Calzadila, S; Hernandez, L; Marsh, KC; WuWong, JR; Opgenorth, TJ Potent and selective non-benzodioxole-containing endothelin-A receptor antagonists. J Med Chem40:322-30 (1997) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Endothelin receptor type B |
---|
Name: | Endothelin receptor type B |
Synonyms: | EDNRB | EDNRB_PIG | Endothelin receptor ET-B |
Type: | PROTEIN |
Mol. Mass.: | 49616.89 |
Organism: | Sus scrofa |
Description: | ChEMBL_63872 |
Residue: | 443 |
Sequence: | MQPLRSLCGRALVALIFACGVAGVQSEERGFPPAGATPPALRTGEIVAPPTKTFWPRGSN
ASLPRSSSPPQMPKGGRMAGPPARTLTPPPCEGPIEIKDTFKYINTVVSCLVFVLGIIGN
STLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPF
IQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEALG
FDMITTDYKGNRLRICLLHPTQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCE
MLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQNDSNRCE
LLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQS
CLKFKANDHGYDNFRSSNKYSSS
|
|
|
BDBM50056080 |
---|
n/a |
---|
Name | BDBM50056080 |
Synonyms: | (2R,3R,4S)-4-Indan-5-yl-2-(4-methoxy-phenyl)-1-[(methyl-propyl-carbamoyl)-methyl]-pyrrolidine-3-carboxylic acid | CHEMBL325444 |
Type | Small organic molecule |
Emp. Form. | C27H34N2O4 |
Mol. Mass. | 450.5699 |
SMILES | CCCN(C)C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(OC)cc1)C(O)=O)c1ccc2CCCc2c1 |
Structure |
|