| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin receptor type B |
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| Ligand | BDBM50056067 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_63873 (CHEMBL671335) |
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| IC50 | 31000±n/a nM |
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| Citation |  Tasker, AS; Sorensen, BK; Jae, HS; Winn, M; von Geldern, TW; Dixon, DB; Chiou, WJ; Dayton, BD; Calzadila, S; Hernandez, L; Marsh, KC; WuWong, JR; Opgenorth, TJ Potent and selective non-benzodioxole-containing endothelin-A receptor antagonists. J Med Chem40:322-30 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin receptor type B |
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| Name: | Endothelin receptor type B |
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| Synonyms: | EDNRB | EDNRB_PIG | Endothelin receptor ET-B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49616.89 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_63872 |
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| Residue: | 443 |
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| Sequence: | MQPLRSLCGRALVALIFACGVAGVQSEERGFPPAGATPPALRTGEIVAPPTKTFWPRGSN
ASLPRSSSPPQMPKGGRMAGPPARTLTPPPCEGPIEIKDTFKYINTVVSCLVFVLGIIGN
STLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPF
IQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEALG
FDMITTDYKGNRLRICLLHPTQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCE
MLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQNDSNRCE
LLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQS
CLKFKANDHGYDNFRSSNKYSSS
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| BDBM50056067 |
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| n/a |
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| Name | BDBM50056067 |
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| Synonyms: | (2R,3R,4S)-4-(3,4-Dimethoxy-phenyl)-2-(4-methoxy-phenyl)-1-[(methyl-propyl-carbamoyl)-methyl]-pyrrolidine-3-carboxylic acid | CHEMBL110794 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H34N2O6 |
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| Mol. Mass. | 470.558 |
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| SMILES | CCCN(C)C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(OC)cc1)C(O)=O)c1ccc(OC)c(OC)c1 |
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| Structure | 
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