Reaction Details |
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Target | Endothelin-1 receptor |
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Ligand | BDBM50056079 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_63343 (CHEMBL679285) |
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IC50 | 1700±n/a nM |
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Citation | Tasker, AS; Sorensen, BK; Jae, HS; Winn, M; von Geldern, TW; Dixon, DB; Chiou, WJ; Dayton, BD; Calzadila, S; Hernandez, L; Marsh, KC; WuWong, JR; Opgenorth, TJ Potent and selective non-benzodioxole-containing endothelin-A receptor antagonists. J Med Chem40:322-30 (1997) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin-1 receptor |
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Name: | Endothelin-1 receptor |
Synonyms: | EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 48256.91 |
Organism: | RAT |
Description: | ENDOTHELIN A EDNRA RAT::P26684 |
Residue: | 426 |
Sequence: | MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCM
LNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSS
HKDSMN
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BDBM50056079 |
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n/a |
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Name | BDBM50056079 |
Synonyms: | (2R,3R,4S)-2-(4-Methoxy-phenyl)-4-(3-methoxy-phenyl)-1-[(methyl-propyl-carbamoyl)-methyl]-pyrrolidine-3-carboxylic acid | CHEMBL326951 |
Type | Small organic molecule |
Emp. Form. | C25H32N2O5 |
Mol. Mass. | 440.532 |
SMILES | CCCN(C)C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(OC)cc1)C(O)=O)c1cccc(OC)c1 |
Structure |
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