| Reaction Details |
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 | Report a problem with these data |
| Target | ERO1-like protein alpha |
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| Ligand | BDBM50505176 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1821570 (CHEMBL4321230) |
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| IC50 | 12190±n/a nM |
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| Citation |  Hayes, KE; Batsomboon, P; Chen, WC; Johnson, BD; Becker, A; Eschrich, S; Yang, Y; Robart, AR; Dudley, GB; Geldenhuys, WJ; Hazlehurst, LA Inhibition of the FAD containing ER oxidoreductin 1 (Ero1) protein by EN-460 as a strategy for treatment of multiple myeloma. Bioorg Med Chem27:1479-1488 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| ERO1-like protein alpha |
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| Name: | ERO1-like protein alpha |
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| Synonyms: | ERO1-L | ERO1-L-alpha | ERO1A | ERO1A_HUMAN | ERO1L | Endoplasmic oxidoreductin-1-like protein | Oxidoreductin-1-L-alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54384.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_716824 |
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| Residue: | 468 |
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| Sequence: | MGRGWGFLFGLLGAVWLLSSGHGEEQPPETAAQRCFCQVSGYLDDCTCDVETIDRFNNYR
LFPRLQKLLESDYFRYYKVNLKRPCPFWNDISQCGRRDCAVKPCQSDEVPDGIKSASYKY
SEEANNLIEECEQAERLGAVDESLSEETQKAVLQWTKHDDSSDNFCEADDIQSPEAEYVD
LLLNPERYTGYKGPDAWKIWNVIYEENCFKPQTIKRPLNPLASGQGTSEENTFYSWLEGL
CVEKRAFYRLISGLHASINVHLSARYLLQETWLEKKWGHNITEFQQRFDGILTEGEGPRR
LKNLYFLYLIELRALSKVLPFFERPDFQLFTGNKIQDEENKMLLLEILHEIKSFPLHFDE
NSFFAGDKKEAHKLKEDFRLHFRNISRIMDCVGCFKCRLWGKLQTQGLGTALKILFSEKL
IANMPESGPSYEFHLTRQEIVSLFNAFGRISTSVKELENFRNLLQNIH
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| BDBM50505176 |
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| n/a |
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| Name | BDBM50505176 |
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| Synonyms: | CHEMBL4589116 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H11ClF3N5O4 |
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| Mol. Mass. | 501.802 |
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| SMILES | OC(=O)c1cc(ccc1Cl)N1N=C(\C(=C/c2ccc(o2)-c2cccc(c2)N=[N+]=[N-])C1=O)C(F)(F)F |c:12| |
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| Structure | 
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