| Reaction Details |
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 | Report a problem with these data |
| Target | Monoacylglycerol lipase ABHD6 |
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| Ligand | BDBM50052781 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1821758 (CHEMBL4321418) |
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| IC50 | 10.0±n/a nM |
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| Citation |  Otrubova, K; Chatterjee, S; Ghimire, S; Cravatt, BF; Boger, DL N-Acyl pyrazoles: Effective and tunable inhibitors of serine hydrolases. Bioorg Med Chem27:1693-1703 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoacylglycerol lipase ABHD6 |
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| Name: | Monoacylglycerol lipase ABHD6 |
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| Synonyms: | ABHD6_MOUSE | Abh6 | Abhd6 | Abhydrolase Domain-Containing Protein 6 | Monoacylglycerol lipase ABHD6 |
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| Type: | Single-pass type II membrane protein; hydrolase |
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| Mol. Mass.: | 38216.17 |
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| Organism: | Mus musculus (mouse) |
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| Description: | Assays were using membranes of recombinant Abh6 transiently transfected in COS-7 cells. |
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| Residue: | 336 |
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| Sequence: | MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYAHHEDYQF
CYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLS
IVGQVKRIHQFVECLKLNKKPFHLIGTSMGGHVAGVYAAYYPSDVCSLSLVCPAGLQYST
DNPFVQRLKELEESAAIQKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHN
SFYRKLFLEIVNEKSRYSLHENMDKIKVPTQIIWGKQDQVLDVSGADILAKSISNSQVEV
LENCGHSVVMERPRKTAKLIVDFLASVHNTDNKKLN
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| BDBM50052781 |
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| n/a |
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| Name | BDBM50052781 |
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| Synonyms: | CHEMBL3318603 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20N4O |
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| Mol. Mass. | 320.3883 |
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| SMILES | O=C(N1CCN(Cc2ccc3ccccc3c2)CC1)n1cccn1 |
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| Structure | 
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