| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50505916 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1824410 (CHEMBL4324174) |
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| IC50 | 91±n/a nM |
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| Citation |  Röhm, S; Berger, BT; Schröder, M; Chaikuad, A; Winkel, R; Hekking, KFW; Benningshof, JJC; Müller, G; Tesch, R; Kudolo, M; Forster, M; Laufer, S; Knapp, S Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors. J Med Chem62:10757-10782 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 41286.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16539 |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50505916 |
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| n/a |
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| Name | BDBM50505916 |
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| Synonyms: | CHEMBL4440391 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H37N5O3 |
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| Mol. Mass. | 515.6465 |
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| SMILES | CC(NC(=O)c1cnn(c1)-c1ccccc1C)c1ccc(cc1)C(=O)N[C@@H](CCC1CCCCC1)C(N)=O |r| |
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| Structure | 
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