| Reaction Details |
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 | Report a problem with these data |
| Target | Nonstructural protein 5A |
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| Ligand | BDBM50505963 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1824460 (CHEMBL4324224) |
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| IC50 | 0.011±n/a nM |
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| Citation |  Ramdas, V; Talwar, R; Banerjee, M; Joshi, AA; Das, AK; Walke, DS; Borhade, P; Dhayagude, U; Loriya, R; Gote, G; Bommakanti, A; Sivaram, A; Agarwal, G; Goswami, A; Nigade, P; Mehta, M; Patil, V; Modi, D; Kumar, H; Mallurwar, S; Dash, A; Modi, F; Kuldharan, S; Srivastava, P; Singh, M; Narasimham, L; Gundu, J; Sharma, S; Kamboj, RK; Palle, VP Discovery and Characterization of Potent Pan-Genotypic HCV NS5A Inhibitors Containing Novel Tricyclic Central Core Leading to Clinical Candidate. J Med Chem62:10563-10582 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nonstructural protein 5A |
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| Name: | Nonstructural protein 5A |
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| Synonyms: | NS5A | Nonstructural protein 5A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48587.20 |
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| Organism: | Hepatitis C virus |
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| Description: | ChEMBL_108438 |
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| Residue: | 447 |
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| Sequence: | SGSWLRDVWDWICTVLTDFKTWLQSKLLPRIPGVPFLSCQRGYKGVWRGDGIMHTTCPCG
AQITGHVKNGSMRIVGPKTCSNTWHGTFPINTYTTGPCTPSPAPNYSRALWRVAAEEYVE
VTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFMVGLN
QYLVGSQLPCEPEPDVTVLTSMLTDPSHITAETAGRRLARGSPPSLASSSASQLSAPSLK
ATCTTRHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPLQAEEDEREVSVPA
EILRKSRKFPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRT
VVLTESTVSSALAELATKTFGSSGSSAVDSGTATAPPDQLPGDGDSGSDVESYSSMPPLE
GEPGDPDLSDGSWSTMSEEASEDVVCC
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| BDBM50505963 |
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| n/a |
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| Name | BDBM50505963 |
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| Synonyms: | CHEMBL4465993 |
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| Type | Small organic molecule |
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| Emp. Form. | C42H50N8O6S |
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| Mol. Mass. | 794.961 |
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| SMILES | [H][C@@]12CC[C@@]([H])(C1)N([C@@H]2c1ncc([nH]1)-c1cc2ccc3cc(ccc3c2s1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C)C(=O)[C@@H](NC(=O)OC)C(C)C |r| |
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| Structure | 
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