| Reaction Details |
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 | Report a problem with these data |
| Target | N-terminal Xaa-Pro-Lys N-methyltransferase 1 |
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| Ligand | BDBM50506000 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1824648 (CHEMBL4324412) |
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| IC50 | >33000±n/a nM |
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| Citation |  Chen, D; Li, L; Diaz, K; Iyamu, ID; Yadav, R; Noinaj, N; Huang, R Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for Nicotinamide J Med Chem62:10783-10797 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| N-terminal Xaa-Pro-Lys N-methyltransferase 1 |
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| Name: | N-terminal Xaa-Pro-Lys N-methyltransferase 1 |
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| Synonyms: | 2.1.1.244 | Alpha N-terminal protein methyltransferase 1A | C9orf32 | METTL11A | Methyltransferase-like protein 11A | N-terminal RCC1 methyltransferase | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed | NRMT | NRMT1 | NRMT1 | NTM1A | NTM1A_HUMAN | NTMT1 | X-Pro-Lys N-terminal protein methyltransferase 1A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 25382.72 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119192 |
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| Residue: | 223 |
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| Sequence: | MTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISSIDINSSRKFLQRFLREGPNKT
GTSCALDCGAGIGRITKRLLLPLFREVDMVDITEDFLVQAKTYLGEEGKRVRNYFCCGLQ
DFTPEPDSYDVIWIQWVIGHLTDQHLAEFLRRCKGSLRPNGIIVIKDNMAQEGVILDDVD
SSVCRDLDVVRRIICSAGLSLLAEERQENLPDEIYHVYSFALR
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| BDBM50506000 |
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| n/a |
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| Name | BDBM50506000 |
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| Synonyms: | CHEMBL4445337 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28N8O6 |
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| Mol. Mass. | 524.5291 |
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| SMILES | N[C@@H](CCN(CC#Cc1cccc(c1)C(N)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r| |
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| Structure | 
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