| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Apelin receptor |
|---|
| Ligand | BDBM50506027 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1824655 (CHEMBL4324419) |
|---|
| EC50 | 0.330000±n/a nM |
|---|
| Citation |  Su, S; Clarke, A; Han, Y; Chao, HJ; Bostwick, J; Schumacher, W; Wang, T; Yan, M; Hsu, MY; Simmons, E; Luk, C; Xu, C; Dabros, M; Galella, M; Onorato, J; Gordon, D; Wexler, R; Gargalovic, PS; Lawrence, RM Biphenyl Acid Derivatives as APJ Receptor Agonists. J Med Chem62:10456-10465 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Apelin receptor |
|---|
| Name: | Apelin receptor |
|---|
| Synonyms: | AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 42664.06 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P35414 |
|---|
| Residue: | 380 |
|---|
| Sequence: | MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD
|
|
|
|---|
| BDBM50506027 |
|---|
| n/a |
|---|
| Name | BDBM50506027 |
|---|
| Synonyms: | CHEMBL4587131 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H28ClFN2O5 |
|---|
| Mol. Mass. | 575.027 |
|---|
| SMILES | CCC[C@@H](NC(=O)c1ccc(c(c1)C(O)=O)-c1cc(Cl)ccc1C(=O)Nc1ccc(OC)c(F)c1)c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
