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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Apelin receptor | ||
| Ligand | BDBM50506033 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1824655 (CHEMBL4324419) | ||
| EC50 | 0.510000±n/a nM | ||
| Citation |  Su, S; Clarke, A; Han, Y; Chao, HJ; Bostwick, J; Schumacher, W; Wang, T; Yan, M; Hsu, MY; Simmons, E; Luk, C; Xu, C; Dabros, M; Galella, M; Onorato, J; Gordon, D; Wexler, R; Gargalovic, PS; Lawrence, RM Biphenyl Acid Derivatives as APJ Receptor Agonists. J Med Chem62:10456-10465 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Apelin receptor | |||
| Name: | Apelin receptor | ||
| Synonyms: | AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 42664.06 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P35414 | ||
| Residue: | 380 | ||
| Sequence: |
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| BDBM50506033 | |||
| n/a | |||
| Name | BDBM50506033 | ||
| Synonyms: | CHEMBL4473653 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C31H26FN3O3 | ||
| Mol. Mass. | 507.5548 | ||
| SMILES | CCC[C@@H](NC(=O)c1ccc(c(c1)C(O)=O)-c1c(F)cccc1-c1nc2ccccc2[nH]1)c1ccccc1 |r,wD:3.35,(27.17,-6.87,;28.49,-6.1,;29.83,-6.87,;31.16,-6.1,;32.5,-6.86,;33.84,-6.1,;33.83,-4.55,;35.17,-6.86,;35.18,-8.41,;36.51,-9.18,;37.84,-8.4,;37.84,-6.86,;36.51,-6.09,;39.17,-6.09,;39.17,-4.55,;40.51,-6.86,;39.17,-9.18,;40.5,-8.4,;41.25,-7.06,;41.83,-9.17,;41.84,-10.72,;40.5,-11.49,;39.16,-10.72,;37.84,-11.49,;36.43,-10.87,;35.4,-12.01,;33.87,-12.01,;33.09,-13.33,;33.86,-14.67,;35.4,-14.67,;36.16,-13.34,;37.67,-13.03,;31.16,-4.56,;32.5,-3.79,;32.49,-2.25,;31.16,-1.48,;29.82,-2.26,;29.83,-3.8,)| | ||
| Structure | 
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