| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 4 |
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| Ligand | BDBM50506164 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1824988 (CHEMBL4324752) |
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| IC50 | 93±n/a nM |
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| Citation |  Werner, S; Mesch, S; Hillig, RC; Ter Laak, A; Klint, J; Neagoe, I; Laux-Biehlmann, A; Dahllöf, H; Bräuer, N; Puetter, V; Nubbemeyer, R; Schulz, S; Bairlein, M; Zollner, TM; Steinmeyer, A Discovery and Characterization of the Potent and Selective P2X4 Inhibitor J Med Chem62:11194-11217 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 4 |
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| Name: | P2X purinoceptor 4 |
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| Synonyms: | ATP receptor | P2RX4 | P2RX4_HUMAN | P2X4 | Purinergic receptor | Purinergic, P2X4 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 43374.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purinergic, P2X4 0 HUMAN::Q99571 |
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| Residue: | 388 |
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| Sequence: | MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSV
VSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIP
DATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLK
AAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAG
HSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYY
RDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYC
MKKRLYYREKKYKYVEDYEQGLASELDQ
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| BDBM50506164 |
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| n/a |
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| Name | BDBM50506164 |
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| Synonyms: | CHEMBL4579675 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20ClN3O5S |
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| Mol. Mass. | 473.929 |
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| SMILES | CC(=O)Nc1cccc(Oc2ccc(NC(=O)Cc3ccccc3Cl)cc2S(N)(=O)=O)c1 |
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| Structure | 
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