| Reaction Details |
|---|
 | Report a problem with these data |
| Target | P2X purinoceptor 4 |
|---|
| Ligand | BDBM50506187 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1824988 (CHEMBL4324752) |
|---|
| IC50 | 10.0±n/a nM |
|---|
| Citation |  Werner, S; Mesch, S; Hillig, RC; Ter Laak, A; Klint, J; Neagoe, I; Laux-Biehlmann, A; Dahllöf, H; Bräuer, N; Puetter, V; Nubbemeyer, R; Schulz, S; Bairlein, M; Zollner, TM; Steinmeyer, A Discovery and Characterization of the Potent and Selective P2X4 Inhibitor J Med Chem62:11194-11217 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| P2X purinoceptor 4 |
|---|
| Name: | P2X purinoceptor 4 |
|---|
| Synonyms: | ATP receptor | P2RX4 | P2RX4_HUMAN | P2X4 | Purinergic receptor | Purinergic, P2X4 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 43374.70 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Purinergic, P2X4 0 HUMAN::Q99571 |
|---|
| Residue: | 388 |
|---|
| Sequence: | MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSV
VSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIP
DATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLK
AAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAG
HSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYY
RDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYC
MKKRLYYREKKYKYVEDYEQGLASELDQ
|
|
|
|---|
| BDBM50506187 |
|---|
| n/a |
|---|
| Name | BDBM50506187 |
|---|
| Synonyms: | CHEMBL4522504 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H19ClN2O4S |
|---|
| Mol. Mass. | 430.905 |
|---|
| SMILES | Cc1ccccc1CC(=O)Nc1ccc(Oc2cccc(Cl)c2)c(c1)S(N)(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
