| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosyl-DNA phosphodiesterase 1 |
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| Ligand | BDBM50507143 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1829127 (CHEMBL4329001) |
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| IC50 | 1010±n/a nM |
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| Citation |  Zakharenko, AL; Luzina, OA; Sokolov, DN; Kaledin, VI; Nikolin, VP; Popova, NA; Patel, J; Zakharova, OD; Chepanova, AA; Zafar, A; Reynisson, J; Leung, E; Leung, IKH; Volcho, KP; Salakhutdinov, NF; Lavrik, OI Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topote?an on in vivo tumor models. Eur J Med Chem161:581-593 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosyl-DNA phosphodiesterase 1 |
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| Name: | Tyrosyl-DNA phosphodiesterase 1 |
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| Synonyms: | TDP1 | TYDP1_HUMAN | Tyrosyl-DNA phosphodiesterase 1 | Tyrosyl-DNA phosphodiesterase 1 (TDP1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 68430.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NUW8 |
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| Residue: | 608 |
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| Sequence: | MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKI
SPVKFSNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVIKKEKDISAPN
DGTAQRTENHGAPACHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNS
GALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHA
QAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSP
LYPRIADGTHKSGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPG
RFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESM
LTLGKESKTPGKSSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKW
SAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELG
VLFLPSAFGLDSFKVKQKFFAGSQEPMATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDT
HGNMWVPS
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| BDBM50507143 |
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| n/a |
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| Name | BDBM50507143 |
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| Synonyms: | CHEMBL4570018 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15NO7S |
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| Mol. Mass. | 401.39 |
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| SMILES | CC(=O)C1=C(O)C=C2Oc3c(c(O)c(C)c(O)c3C(=O)CSC#N)[C@@]2(C)C1=O |r,c:3,t:6| |
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| Structure | 
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