Reaction Details |
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Target | Mu-type opioid receptor |
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Ligand | BDBM50059792 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_149139 (CHEMBL759230) |
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Ki | 212±n/a nM |
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Citation | Grauert, M; Bechtel, WD; Ensinger, HA; Merz, H; Carter, AJ Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as antagonists of the NMDA receptor-channel complex. J Med Chem40:2922-30 (1997) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mu-type opioid receptor |
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Name: | Mu-type opioid receptor |
Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44503.11 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
Residue: | 398 |
Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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BDBM50059792 |
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n/a |
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Name | BDBM50059792 |
Synonyms: | (2R,6S,11S)-3-((R)-2-Methoxy-propyl)-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol | CHEMBL317505 |
Type | Small organic molecule |
Emp. Form. | C18H27NO2 |
Mol. Mass. | 289.4125 |
SMILES | CO[C@H](C)CN1CC[C@@]2(C)[C@H](C)[C@H]1Cc1ccc(O)cc21 |THB:4:5:10:20.14.13| |
Structure |
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