| Reaction Details |
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 | Report a problem with these data |
| Target | Urotensin-2 receptor |
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| Ligand | BDBM50508380 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1832932 (CHEMBL4332940) |
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| IC50 | 43±n/a nM |
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| Citation |  Lim, CJ; Kim, NH; Park, HJ; Lee, BH; Oh, KS; Yi, KY Synthesis and SAR of 5-aryl-furan-2-carboxamide derivatives as potent urotensin-II receptor antagonists. Bioorg Med Chem Lett29:577-580 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urotensin-2 receptor |
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| Name: | Urotensin-2 receptor |
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| Synonyms: | G-protein coupled receptor 14 | GPR14 | UR-II-R | UR2R_HUMAN | UTS2R | Urotensin II receptor | Urotensin-II |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 42159.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Urotensin-II UTS2R HUMAN::Q9UKP6 |
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| Residue: | 389 |
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| Sequence: | MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSA
MGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGD
VGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLL
TLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRR
SQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLT
TCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLS
SCSPQPTDSLVLAPAAPARPAPEGPRAPA
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| BDBM50508380 |
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| n/a |
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| Name | BDBM50508380 |
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| Synonyms: | CHEMBL4437489 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H29ClN4O3 |
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| Mol. Mass. | 505.008 |
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| SMILES | Clc1cc(CN2CCN(CC2)C(=O)c2ccc(o2)-c2cccc(c2)C#N)ccc1OC1CCNCC1 |
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| Structure | 
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