Reaction Details |
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Target | Steroid 17-alpha-hydroxylase/17,20 lyase |
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Ligand | BDBM50061172 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_50389 (CHEMBL662845) |
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IC50 | 32±n/a nM |
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Citation | Ling, YZ; Li, JS; Liu, Y; Kato, K; Klus, GT; Brodie, A 17-Imidazolyl, pyrazolyl, and isoxazolyl androstene derivatives. Novel steroidal inhibitors of human cytochrome C17,20-lyase (P450(17 alpha). J Med Chem40:3297-304 (1997) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Steroid 17-alpha-hydroxylase/17,20 lyase |
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Name: | Steroid 17-alpha-hydroxylase/17,20 lyase |
Synonyms: | CP17A_RAT | Cyp17 | Cyp17a1 | Cytochrome P450 17,20 lyase | Cytochrome P450 17A1 | Cytochrome P450-C17 | Steroid 17-alpha-hydroxylase/17,20 lyase |
Type: | Enzyme |
Mol. Mass.: | 57255.68 |
Organism: | Rattus norvegicus (Rat) |
Description: | P11715 |
Residue: | 507 |
Sequence: | MWELVGLLLLILAYFFWVKSKTPGAKLPRSLPSLPLVGSLPFLPRRGHMHVNFFKLQEKY
GPIYSLRLGTTTTVIIGHYQLAREVLIKKGKEFSGRPQMVTQSLLSDQGKGVAFADAGSS
WHLHRKLVFSTFSLFKDGQKLEKLICQEAKSLCDMMLAHDKESIDLSTPIFMSVTNIICA
ICFNISYEKNDPKLTAIKTFTEGIVDATGDRNLVDIFPWLTIFPNKGLEVIKGYAKVRNE
VLTGIFEKCREKFDSQSISSLTDILIQAKMNSDNNNSCEGRDPDVFSDRHILATVGDIFG
AGIETTTTVLKWILAFLVHNPEVKKKIQKEIDQYVGFSRTPTFNDRSHLLMLEATIREVL
RIRPVAPMLIPHKANVDSSIGEFTVPKDTHVVVNLWALHHDENEWDQPDQFMPERFLDPT
GSHLITPTQSYLPFGAGPRSCIGEALARQELFVFTALLLQRFDLDVSDDKQLPRLEGDPK
VVFLIDPFKVKITVRQAWMDAQAEVST
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BDBM50061172 |
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n/a |
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Name | BDBM50061172 |
Synonyms: | (10R,13S)-17-Isoxazol-5-yl-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15-dodecahydro-cyclopenta[a]phenanthren-3-one | CHEMBL78215 |
Type | Small organic molecule |
Emp. Form. | C22H27NO2 |
Mol. Mass. | 337.4553 |
SMILES | C[C@]12CCC3C(CCC4=CC(=O)CC[C@]34C)C1CC=C2c1ccno1 |c:21,t:8| |
Structure |
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