| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase |
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| Ligand | BDBM50508777 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1834347 (CHEMBL4334355) |
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| IC50 | 166±n/a nM |
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| Citation |  Pribut, N; Basson, AE; van Otterlo, WAL; Liotta, DC; Pelly, SC Aryl Substituted Benzimidazolones as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors. ACS Med Chem Lett10:196-202 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Reverse transcriptase |
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| Name: | Reverse transcriptase |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 29598.37 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WKE8 |
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| Residue: | 254 |
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| Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
|
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| BDBM50508777 |
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| n/a |
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| Name | BDBM50508777 |
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| Synonyms: | CHEMBL4438953 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H14N4O2 |
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| Mol. Mass. | 330.3401 |
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| SMILES | CCn1c2c(Oc3cc(\C=C\C#N)cc(c3)C#N)cccc2[nH]c1=O |
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| Structure | 
|
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