Reaction Details |
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Target | Phosphodiesterase |
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Ligand | BDBM50061896 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_156453 (CHEMBL764831) |
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IC50 | 55000±n/a nM |
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Citation | Xia, Y; Chackalamannil, S; Czarniecki, M; Tsai, H; Vaccaro, H; Cleven, R; Cook, J; Fawzi, A; Watkins, R; Zhang, H Synthesis and evaluation of polycyclic pyrazolo[3,4-d]pyrimidines as PDE1 and PDE5 cGMP phosphodiesterase inhibitors. J Med Chem40:4372-7 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Phosphodiesterase |
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Name: | Phosphodiesterase |
Synonyms: | Heart phosphodiesterase | Phosphodiesterase 3B |
Type: | PROTEIN |
Mol. Mass.: | 124301.20 |
Organism: | Bos taurus |
Description: | ChEMBL_156453 |
Residue: | 1115 |
Sequence: | MRRDERDAKAMRSPPPPDGAASPPESVRNGYVKGCVSPLRQDPPRGFFFHLCRFCNVELL
LPPPASPQQPRRGSPFSRARLLLGALAAFVLALLLGSGPESWAAGAARLRTLLSVCSQSL
SPLFSIACAFFFLTCFLTRTKRGAGPGRSGGGSWWLLALPACCYLGDFLVGQWESWSRGD
GDARAPVPHTPPAVAGRWFLVLSCVGLLTLAQPGRLRHSIVVLLFSSFVWWVSFTSLGAL
PPALRPLLSCLVGGVGCLLALGLDHFFQIREAPQQPQLSSTAEEKVPVIRPRRRSSCVSF
GETSGGYYGSCKMFRRPSLPCISREQMILWDWDLKQWYKPHYQISGGGSGVDLSVLNEAR
NMVSDLLVDPTLPPQVIASLRSISSLMGAFSGSCRPKMNPLTPFPGFYPCSEIEDPAEKG
DRKLHKGLNSRNSLPTPHLRRSSGTSGLPPIDQTSPRWERNNGKRPHQEFGILSQGCYLN
GPFSSNLLTVPKQRSSSVSLTHHVGLRRAGGLPSMNSPSHGPVSAGSPANRSPIEFPDTA
EFLTKPPVILHKSLSSTPNSPDFYQQLRNSDSNLCNSCGHQILKYDSASEPESGTDCHRE
KSGGEDNTVFSKASFNLTEAQQEVETENRDGRKLLWEGENHLKAAAQNEEQPNIEQEASQ
DLILIEDYDSLIENMSNWNFQIFELVEKMGEKSGRILSQVVYTLFQDTGLLEIFKIPTLQ
FMNYFHALENGYRDIPYHNRIHATDVLHAVWYLTTRPIPGLQEIHSDHGAGNETAINPER
IAYISSRSCSIPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVL
YNDRSVLENHHAASAWTLYLSRPEYNFLLNLDNVEFKRFRFLVIEAILATDLKKHFDFLA
EFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPTKVRDLHLKWTEGIVNEFYEQG
DEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWIESEEDDDTE
SCYEEEDAEELDTEDEEIEDNLNSKPQRRKGRRQIFCQLMHHLTENHKIWKEIIEEEEKC
KADGNKLQMENSSLPQGDEIQVIEEADEEEERQLE
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BDBM50061896 |
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n/a |
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Name | BDBM50061896 |
Synonyms: | CHEMBL343971 | Rac-(6aR*,9aS*)-5,6a,7,8,9,9a-Hexahydro-5-methyl-1-(phenylmethyl)cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(1H)-one |
Type | Small organic molecule |
Emp. Form. | C18H19N5O |
Mol. Mass. | 321.3764 |
SMILES | CN1C2=N[C@@H]3CCC[C@@H]3N2c2c(cnn2Cc2ccccc2)C1=O |t:2| |
Structure |
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